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UniProt is updated every four weeks (see FAQ on how to be notified automatically of updates). You can download small data sets and subsets directly from this website by following the download link on any search result page. For downloading complete data sets we recommend using If you are located in Europe, the Middle East or Africa, you may want to download data from our mirror site in the United Kingdom or in Switzerland instead. If you need to use a secure file transfer protocol, you can download the same data via https.

See also: Downloaded data seems incomplete or corrupted - how can I get help with download problems?

Here are the main sections of our FTP site, with links to README files and help pages and some frequently downloaded files:

Parent directory
Reviewed (Swiss-Prot)

The section of UniProtKB which has been reviewed by our curators.

xml | fasta | text
Unreviewed (TrEMBL) The section of UniProtKB which has been automatically imported. i / FAQxml | fasta | text
Isoform sequences The non canonical isoforms of UniProtKB Swiss-Prot (reviewed) entries. i / FAQfasta
Taxonomic divisions / README
Reference proteomes / README
Pan proteomes / README
ID mapping / README
Proteomics mapping / README
Variants / README
Genome annotation tracks / README
XML schema
Parent directory
UniRef100 / READMExml | fasta
UniRef90 / READMExml | fasta
UniRef50 / READMExml | fasta
XML schema
Parent directory / README
UniParc (Sequence Archive) / Helpxml | fasta
XML schema

UniProt RDF distribution All data provided by the UniProt consortium in RDF format, including supporting datasets. i

Parent directory / README
OWL schema
Releases notes
Previous releases
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